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Editors' Choice

Nancy R. Gough
30 March 2010: ec92.
In fish, the calcium channel required for excitation-contraction coupling does not conduct calcium. Abstract »  
Paula A. Kiberstis
30 March 2010: ec93.
A change in the distribution of a signaling molecule on the surface of heart muscle cells may contribute to heart failure. Abstract »  
Elizabeth M. Adler
30 March 2010: ec94.
Denervation makes muscles more responsive to the muscle-wasting cytokine TWEAK. Abstract »  
L. Bryan Ray
30 March 2010: ec95.
A mutation in the leptin receptor causes adult-onset and diet-induced obesity in mice. Abstract »  
John F. Foley
30 March 2010: ec96.
Membranous tubular connections between natural killer cells and their targets facilitate long-distance killing. Abstract »  
Nancy R. Gough
30 March 2010: ec97.
Silencing of transposable elements by ARGONAUTE 9 is necessary to specify a single female gamete in Arabidopsis. Abstract »  
L. Bryan Ray
30 March 2010: ec98.
Simple changes in signaling mechanisms can explain variation in tooth morphology in a wild population of seals. Abstract »  
Valda Vinson
30 March 2010: ec99.
Structural data might provide a foundation to develop specific inhibitors to a class of phosphoinositide 3-kinases. Abstract »  
Paula A. Kiberstis
30 March 2010: ec100.
The self-renewing cells that drive the growth of leukemia arise, in part, through activation of a well-known cell signaling pathway. Abstract »  
Stella M. Hurtley
30 March 2010: ec101.
Spontaneous synaptic vesicle fusion is triggered by soluble proteins that compete with synaptotagmins to induce membrane curvature. Abstract »  

 

Podcasts

Dario R. Alessi and Annalisa M. VanHook
30 March 2010: pc7.
The tumor suppressor LKB1 not only keeps cell proliferation in check but also modulates cell adhesion. Abstract »   Full Text »   Podcast »  

 

Research Articles

Ivan Bogeski, Carsten Kummerow, Dalia Al-Ansary, Eva C. Schwarz, Richard Koehler, Daisuke Kozai, Nobuaki Takahashi, Christine Peinelt, Desiree Griesemer, Monika Bozem, Yasuo Mori, Markus Hoth, and Barbara A. Niemeyer
30 March 2010: ra24.
Redox sensitivity of T cells decreases through ORAI Ca2+ channel subunit switching during T cell differentiation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Anna Zagórska, Maria Deak, David G. Campbell, Sourav Banerjee, Mariko Hirano, Shinichi Aizawa, Alan R. Prescott, and Dario R. Alessi
30 March 2010: ra25.
The kinase NUAK1, which is linked to tumor invasion, promotes cell detachment by activating cytoskeletal motor proteins. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Nevin A. Lambert
30 March 2010: pe12.
Oligomers of G protein–coupled receptors may be less stable than previously suspected. Abstract »   Full Text »   PDF »  

 

Reviews

Peter Vandenabeele, Wim Declercq, Franky Van Herreweghe, and Tom Vanden Berghe
30 March 2010: re4.
Programmed necrosis in response to TNF requires the activity of two serine-threonine kinases. Gloss »   Abstract »   Full Text »   PDF »  
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