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Editors' Choice

Elizabeth M. Adler
13 April 2010: ec108.
VEGF-B regulates endothelial fatty acid transport and thereby lipid disposition by stimulating the production of fatty acid transport proteins. Abstract »  
Paula A. Kiberstis
13 April 2010: ec109.
The innate immune system may promote metabolic health through effects on gut microbes. Abstract »  
Wei Wong
13 April 2010: ec110.
Nuclear translocation of the cGMP-activated kinase EGL-4 is required for long-term odor adaptation in Caenorhabditis elegans. Abstract »  
John F. Foley
13 April 2010: ec111.
Activation of Toll-like receptor 4 by the chromatin-associated protein HMGB1 triggers epileptic seizures in mice. Abstract »  
Annalisa M. VanHook
13 April 2010: ec112.
cAMP activation of estrogen receptor {alpha} requires PKA-mediated phosphorylation of the arginine methyltransferase CARM1. Abstract »  
Paula A. Kiberstis
13 April 2010: ec113.
Arsenic, a drug used clinically for leukemia, binds directly to an oncogenic protein, thereby promoting its degradation. Abstract »  

 

Research Articles

Laura Poliseno, Leonardo Salmena, Luisa Riccardi, Alessandro Fornari, Min Sup Song, Robin M. Hobbs, Paolo Sportoletti, Shorheh Varmeh, Ainara Egia, Giuseppe Fedele, Lucia Rameh, Massimo Loda, and Pier Paolo Pandolfi
13 April 2010: ra29.
A microRNA network regulates the tumor suppressor PTEN in prostate cancer. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Ljiljana Milenkovic and Matthew P. Scott
13 April 2010: pe14.
Protein kinase A orchestrates Hedgehog signaling from the base of the primary cilium. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882