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Editors' Choice

Nancy R. Gough
20 April 2010: ec114.
Degradation of a growth factor receptor in the distal axon prevents its retrograde delivery and function as a long-distance neurotrophic factor. Abstract »  
Elizabeth M. Adler
20 April 2010: ec115.
Snakes sense infrared radiation through the temperature-dependent activation of the TRPA1 ion channel. Abstract »  
Wei Wong
20 April 2010: ec116.
ER stress selectively induces mRNA translation of a p53 isoform. Abstract »  
L. Bryan Ray
20 April 2010: ec117.
An enzyme that chops up RNA can be switched to DNA fragmentation and can trigger programmed cell death in worms. Abstract »  
Peter R. Stern
20 April 2010: ec118.
A signaling complex serves as a synapse organizer that acts bidirectionally on both pre- and postsynaptic components. Abstract »  
Nancy R. Gough
20 April 2010: ec119.
The Notch intracellular domain appears to serve as a cell survival factor by preventing mitochondrial damage. Abstract »  
L. Bryan Ray
20 April 2010: ec120.
Systematic swapping of modular protein domains verifies a mechanism for generation of phenotypic diversity in yeast. Abstract »  
Kristen Mueller
20 April 2010: ec121.
Suppressive T cells repurpose inflammatory signaling pathways to promote their suppressive functions. Abstract »  
L. Bryan Ray
20 April 2010: ec122.
A wavy hair phenotype reveals channel-receptor crosstalk in the mouse. Abstract »  


Journal Club

B. Ian Hutchins
20 April 2010: jc1.
Differences in neurite cyclic nucleotide concentrations regulate their differential outgrowth. Abstract »   Full Text »   PDF »  
Muhammad Munir
20 April 2010: jc2.
Influenza A virus suppresses the host interferon response by interfering with the RIG-I and TRIM25 antiviral molecules. Abstract »   Full Text »   PDF »  
Raphael Schneider
20 April 2010: jc3.
Some subsets of differentiated T cells retain phenotypic plasticity. Abstract »   Full Text »   PDF »  



Seth I. Berger, Ravi Iyengar, and Annalisa M. VanHook
20 April 2010: pc8.
Integrating interactome and genetics data allows researchers to predict adverse drug effects. Abstract »   Full Text »   Podcast »  


Research Articles

Seth I. Berger, Avi Ma’ayan, and Ravi Iyengar
20 April 2010: ra30.
Integration of drug and protein interaction data with genetic data enables prediction of adverse drug effects. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882