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Editors' Choice

Elizabeth M. Adler
4 May 2010: ec128.
Corticotrophin-releasing factor (CRF) signaling through CRFR1 recruits serotonin receptors to the cell surface, thereby enhancing anxiety-related behaviors. Abstract »  
Wei Wong
4 May 2010: ec129.
Cholesterol crystals form in early atherosclerotic lesions and activate inflammatory responses. Abstract »  
Nancy R. Gough
4 May 2010: ec130.
By promoting an inhibitory autophosphorylation event, the ATPase XP24 decreases immune responses mediated by the XA21 pattern recognition receptor. Abstract »  
John F. Foley
4 May 2010: ec131.
G{alpha}q acts as a scaffold protein to assemble activators of the mitogen-activated protein kinase ERK5. Abstract »  
L. Bryan Ray
4 May 2010: ec132.
The multifunctional protein TAZ links developmental signaling pathways and is implicated in kidney disease. Abstract »  
Annalisa M. VanHook
4 May 2010: ec133.
ErbB3, long thought to be a pseudokinase, exhibits catalytic activity in vitro. Abstract »  
Stella M. Hurtley
4 May 2010: ec134.
Bacteria secrete an unusual form of amino acids to escape from aging communities by dissolving the surrounding matrix. Abstract »  
Nancy R. Gough
4 May 2010: ec135.
By bringing the Rap1 effector RapL to the membrane, the adaptor SKAP1 promotes adhesion, allowing activated T cell receptors to decrease T cell motility. Abstract »  
Elizabeth M. Adler
4 May 2010: ec136.
Adiponectin signaling through AdipoR1 plays a crucial role in regulating muscle mitochondrial function. Abstract »  
Valda Vinson
4 May 2010: ec137.
Fleeting molecular events are observed as light illuminates chlorophyll to initiate photosynthesis. Abstract »  

 

Podcasts

Christina H. Eng, Robert T. Abraham, and Annalisa M. VanHook
4 May 2010: pc9.
Ammonia induces autophagy, which may help cancer cells survive stressful conditions. Abstract »   Full Text »   Podcast »  

 

Research Articles

Tomonori Kaneko, Haiming Huang, Bing Zhao, Lei Li, Huadong Liu, Courtney K. Voss, Chenggang Wu, Martin R. Schiller, and Shawn Shun-Cheng Li
4 May 2010: ra34.
Selective blocking of binding pockets by surface loops defines the specificity of a phosphotyrosine-binding domain. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  Interactive Figures »  
David Q. Matus, Xiao-Yan Li, Sarah Durbin, Daniel Agarwal, Qiuyi Chi, Stephen J. Weiss, and David R. Sherwood
4 May 2010: ra35.
A Caenorhabditis elegans screen provides insight into cell invasion and metastasis. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Jonathan C. Kagan
4 May 2010: pe15.
A common oral pathogen uses the C5a receptor to selectively inhibit some TLR2 responses. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882