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Editors' Choice

Elizabeth M. Adler
11 May 2010: ec138.
Cardiac copper deficiency elicits a circulating signal that leads to an increase in circulating copper and in the abundance of a copper transporter in liver and intestine. Abstract »  
Wei Wong
11 May 2010: ec139.
Dietary absorption of vitamins A and D decreases bile acid synthesis through nuclear receptor–mediated transcriptional regulation. Abstract »  
Nancy R. Gough
11 May 2010: ec140.
The tumor microenvironment controls the intensity of cancer-associated Wnt signaling. Abstract »  
Kristen L. Mueller
11 May 2010: ec141.
An immunotolerant microenvironment driven by chemokine expression contributes to tumor growth and spread. Abstract »  
L. Bryan Ray
11 May 2010: ec142.
A receptor protein helps avoid excessive activation of immune responses to invading pathogens. Abstract »  
John F. Foley
11 May 2010: ec143.
Time-lapse microscopy reveals how Notch integrates signals from Delta molecules on the same cell with those from a neighboring cell. Abstract »  
Stella M. Hurtley
11 May 2010: ec144.
A synaptic vesicle protein must be membrane-anchored to stimulate fusion in vitro at physiological Ca2+ concentrations. Abstract »  
Caroline Ash
11 May 2010: ec145.
Variable maturation of a dengue viral antigen results in incomplete neutralization and promotes secondary pathology. Abstract »  
L. Bryan Ray
11 May 2010: ec146.
The time delay in transcriptional regulatory systems sets important constraints on biological control systems. Abstract »  



David Q. Matus, David R. Sherwood, and Annalisa M. VanHook
11 May 2010: pc10.
Genes that affect development of the nematode gonad are implicated in cell invasion and metastasis. Abstract »   Full Text »   Podcast »  


Research Articles

Marco A. Purbhoo, Hebin Liu, Stephane Oddos, Dylan M. Owen, Mark A. A. Neil, Sophie V. Pageon, Paul M. W. French, Christopher E. Rudd, and Daniel M. Davis
11 May 2010: ra36.
Vesicles dynamically deliver the T cell adaptor protein LAT to sites of T cell signalosomes. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Kristin K. Jernigan, Christopher S. Cselenyi, Curtis A. Thorne, Alison J. Hanson, Emilios Tahinci, Nicole Hajicek, William M. Oldham, Laura A. Lee, Heidi E. Hamm, John R. Hepler, Tohru Kozasa, Maurine E. Linder, and Ethan Lee
11 May 2010: ra37.
A Xenopus reconstitution system reveals that the G protein Gβ{gamma} subunit contributes to β-catenin stabilization. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Daniel D. Billadeau
11 May 2010: pe16.
Subsynaptic vesicles that contain the adaptor protein linker of activated T cells regulate T cell signaling. Abstract »   Full Text »   PDF »  



11 May 2010: er2.
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11 May 2010: er3.
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11 May 2010: er4.
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11 May 2010: er5.
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882