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Cover Figure

ONLINE COVER This week's issue features a Research Article that shows that intracellular vesicles containing the transmembrane adaptor protein LAT migrate to and interact with protein microclusters at the interface between a T cell and an antigen-presenting cell. The image shows vesicular LAT (red) and microclusters containing the T cell receptor–associated kinase ZAP-70 (green) at the interface between a Jurkat T cell and a coverslip coated with an activating antibody. [Image: Marco Purbhoo, Imperial College London, UK]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882