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Editors' Choice

John F. Foley
25 May 2010: ec155.
Coupling to antigen-presenting cells through the T cell receptor renders T cells sensitive to mechanical force. Abstract »  
Stella M. Hurtley
25 May 2010: ec156.
Intravacuolar Salmonella sense host cytosolic pH, resulting in degradation of a regulatory complex and effector translocation. Abstract »  
Elizabeth M. Adler
25 May 2010: ec157.
Generation of signals crucial to arterial morphogenesis depends on VEGFR2 trafficking mechanisms that limit its exposure to the phosphatase PTP1b. Abstract »  
Valda Vinson
25 May 2010: ec158.
Stochastic pulsing of individual cells plays a critical role in initiating cAMP pulses. Abstract »  
L. Bryan Ray
25 May 2010: ec159.
Phosphorylation reactions in budding yeast reveal the regulatory architecture of a fundamental cellular control system. Abstract »  
L. Bryan Ray
25 May 2010: ec160.
A bacterial regulatory network is compared to a computer operating system. Abstract »  

 

Podcasts

Wei Hsu and Annalisa M. VanHook
25 May 2010: pc11.
The balance between WNT and FGF signaling influences the mode of bone formation in the skull. Abstract »   Full Text »   Podcast »  

 

Research Articles

Takamitsu Maruyama, Anthony J. Mirando, Chu-Xia Deng, and Wei Hsu
25 May 2010: ra40.
Imbalance of WNT and FGF signaling promotes premature closure of skull bones by inducing bone formation through chondrogenesis. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Bahram Razani, Brian Zarnegar, A. Jimmy Ytterberg, Travis Shiba, Paul W. Dempsey, Carl F. Ware, Joseph A. Loo, and Genhong Cheng
25 May 2010: ra41.
Feedback inhibition of the central regulator of noncanonical NF-{kappa}B signaling is mediated by its target kinase. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Chong-Shan Shi and John H. Kehrl
25 May 2010: ra42.
Regulation of the ubiquitination of Beclin-1 may be a general mechanism that controls autophagy. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Shao-Cong Sun
25 May 2010: pe18.
A component of the I{kappa}B kinase complex mediates feedback inhibition of the kinase NIK. Abstract »   Full Text »   PDF »  

 

Errata

 
25 May 2010: er6.
Full Text »   PDF »  
 
25 May 2010: er7.
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882