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ONLINE COVER This week's issue features a Research Article describing how the combination of increased Wnt signaling and reduced fibroblast growth factor receptor (FGFR) signaling results in premature closure of the skull bones through a process involving chondrogenesis. These studies in mice provide insight into the congenital disorder known as craniosynostosis, which is caused by premature closure of the skull bones. The image shows the regions of a 7-day-old mouse skull where Fgfr1 was deleted. [Image: Takamitsu Maruyama and Wei Hsu, University of Rochester Medical Center]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882