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Editors' Choice

Nancy R. Gough
1 June 2010: ec161.
The transcription factor IRF-3 acts at the mitochondria to trigger apoptosis of virally infected cells. Abstract »  
John F. Foley
1 June 2010: ec162.
The death receptor CD95 (Fas) is required for the growth of tumor cells. Abstract »  
L. Bryan Ray
1 June 2010: ec163.
Control of cell proliferation and control of cell size are separately regulated in mammals. Abstract »  
Paula A. Kiberstis
1 June 2010: ec164.
In mice, the development of energy-burning brown fat is regulated by an enzyme that is critical for prostaglandin synthesis. Abstract »  
Kristen L. Mueller
1 June 2010: ec165.
Cells that ensheath blood vessels promote exit of the developing T lymphocytes from the thymus. Abstract »  
Valda Vinson
1 June 2010: ec166.
Some metazoan and fungal host defense peptides are specific inhibitors of bacterial peptidoglycan biosynthesis. Abstract »  


Research Articles

Roi Avraham, Aldema Sas-Chen, Ohad Manor, Israel Steinfeld, Reut Shalgi, Gabi Tarcic, Noa Bossel, Amit Zeisel, Ido Amit, Yaara Zwang, Espen Enerly, Hege G. Russnes, Francesca Biagioni, Marcella Mottolese, Sabrina Strano, Giovanni Blandino, Anne-Lise Børresen-Dale, Yitzhak Pilpel, Zohar Yakhini, Eran Segal, and Yosef Yarden
1 June 2010: ra43.
Some cancers showed decreased abundance of a subset of EGF-regulated microRNAs, which allows the production of oncogenic transcription factors. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Jason S. White, Serah Choi, and Christopher J. Bakkenist
1 June 2010: ra44.
Radiation triggers distinct responses in cells in which the kinase ATM is transiently inhibited versus those that have adapted to its loss. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Guillermo Mariño and Guido Kroemer
1 June 2010: pe19.
A volatile metabolic by-product can induce autophagy in an autocrine and paracrine fashion. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882