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Editors' Choice

L. Bryan Ray
8 June 2010: ec167.
A mechanism is revealed for cells to convert a mechanical signal into a biochemical one. Abstract »  
Wei Wong
8 June 2010: ec168.
A factor secreted from anterior neurons in Caenorhabditis elegans protects germ cells from apoptosis. Abstract »  
L. Bryan Ray
8 June 2010: ec169.
A tumor suppressor appears to protect against aberrant chromosome breakage during meiosis. Abstract »  
Elizabeth M. Adler
8 June 2010: ec170.
Elements of the mitochondrial apoptosis pathway are used to mediate long-term depression of synaptic function. Abstract »  
Nancy R. Gough
8 June 2010: ec171.
Ubiquitylation of a fungal arrestin is sufficient to activate signaling. Abstract »  
Peter R. Stern
8 June 2010: ec172.
Pharmacological agents can be used to treat disorders of pathological fear without reactivating the original memory trace. Abstract »  
Stella M. Hurtley
8 June 2010: ec173.
Genetically encoded biosensors visualize the dynamics of a global signaling molecule within bacterial cells. Abstract »  
Stella M. Hurtley
8 June 2010: ec174.
Membrane-sculpting proteins nucleate clathrin-coated pits during endocytosis. Abstract »  
Kristen L. Mueller
8 June 2010: ec175.
Blockade of an enzyme that promotes inflammation results in protection from lethal sepsis. Abstract »  
Stella M. Hurtley
8 June 2010: ec176.
In developing Caenorhabditis elegans during neuronal arborization, excess neurite branches are retracted and fuse. Abstract »  
L. Bryan Ray
8 June 2010: ec177.
An expanded role in promoting longevity is defined for a signaling protein in the unfolded protein response pathway. Abstract »  

 

Podcasts

Howard A. Rockman and Annalisa M. VanHook
8 June 2010: pc12.
Mechanical stimulation of the angiotensin receptor promotes cell survival by preferentially activating β-arrestin–dependent signaling. Abstract »   Full Text »   Podcast »  

 

Research Articles

Yu Chen, Yongli Yao, Yuka Sumi, Andrew Li, Uyen Kim To, Abdallah Elkhal, Yoshiaki Inoue, Tobias Woehrle, Qin Zhang, Carl Hauser, and Wolfgang G. Junger
8 June 2010: ra45.
Neutrophil activation by infectious and inflammatory signals requires ATP release and its feedback through purinergic receptors. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Kriti Rakesh, ByungSu Yoo, Il-Man Kim, Natasha Salazar, Ki-Seok Kim, and Howard A. Rockman
8 June 2010: ra46.
Mechanical stress on hearts triggers β-arrestin–dependent cell survival signaling through the angiotensin receptor. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

R. Suzanne Zukin
8 June 2010: pe20.
Polycomb group proteins promote the acquisition of ischemic tolerance in neurons. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882