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ONLINE COVER This week kicks off a series of issues about the evolution of signaling molecules and networks. The Editorial by Linding describes three levels at which signaling systems may evolve and emphasizes that the evolution of cells within our lifetime under changing genomic conditions may contribute to diseases, such as cancer. The Perspective by De Robertis highlights the insight gained from the flatworm Planaria into the evolution of signaling pathways that control early stages of pattern formation. Panzano et al. discuss how understanding the molecular nature of heat sensing in pit vipers provides insight into the evolution of thermosensing. The image shows a Western diamondback rattlesnake. [Image: Photos.com]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882