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Editors' Choice

L. Bryan Ray
29 June 2010: ec191.
A screen in yeast uncovers new signaling components in the pheromone response pathway. Abstract »  
Nancy R. Gough
29 June 2010: ec192.
Switching to sexual reproduction requires a specific phosphorylation of RNA polymerase II at the master regulator gene ste11. Abstract »  
Elizabeth M. Adler
29 June 2010: ec193.
Engineering commensal bacteria to signal to Vibrio cholerae could provide an approach to cholera prophylaxis. Abstract »  
Kristen L. Mueller
29 June 2010: ec194.
Immunoglobulin responses against nonpathogenic bacteria in the gut are specific for the resident microbial flora. Abstract »  
Wei Wong
29 June 2010: ec195.
The ubiquitin E3 ligase TRAF2 requires sphingosine 1-phosphate for its activity. Abstract »  
Kristen L. Mueller
29 June 2010: ec196.
Pathways that reduce cholesterol in atherosclerosis also suppress increased immune cell numbers associated with the disease. Abstract »  
Annalisa M. VanHook
29 June 2010: ec197.
Proteolytic cleavage of the receptor Robo is required for axonal repulsion in Drosophila. Abstract »  
John F. Foley
29 June 2010: ec198.
Mutations in presenilin 1 associated with familial Alzheimer’s disease prevent acidification of lysosomes and block autophagy. Abstract »  
Wei Wong
29 June 2010: ec199.
In addition to oxidative stress, the transcription factor Nrf2 can also be activated by impaired autophagy. Abstract »  
Stella M. Hurtley
29 June 2010: ec200.
Within the host cell, a small secondary signaling molecule from a pathogen triggers a pathway of innate immunity. Abstract »  
Peter R. Stern
29 June 2010: ec201.
Loss of glutamate receptor–dependent synaptic plasticity in the brain is associated with the transition to cocaine addiction. Abstract »  


Editorial Guides

Nancy R. Gough and Wei Wong
29 June 2010: eg5.
With the wealth of data in genomics and proteomics, scientists can begin to investigate how signaling systems evolved. Abstract »   Full Text »   PDF »   Evolution Series II »  



Christopher J. Howe and Annalisa M. VanHook
29 June 2010: pc13.
Analysis of TOR signaling pathway evolution may shed light on the early divergence of eukaryotic lineages. Abstract »   Full Text »   Podcast »  


Research Articles

Jaco Serfontein, R. Ellen R. Nisbet, Christopher J. Howe, and Petrus J. de Vries
29 June 2010: ra49.
The TSC1/TSC2-TOR signaling pathway evolved from a primitive signaling pathway linking adenosine monophosphate abundance to cell growth. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Kristin Wuichet and Igor B. Zhulin
29 June 2010: ra50.
The bacterial chemotaxis system evolved from simpler regulatory proteins that primarily control transcription. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Orkun S. Soyer
29 June 2010: pe23.
Genomic analysis reveals missing links in the evolution of chemotaxis systems. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882