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ONLINE COVER This week features the second issue in the series about the evolution of signaling molecules and networks. The Editorial Guide includes examples of how analysis of molecule and network evolution is revealing insights for protein engineering, uncovering previously unknown signaling intermediates, and even guiding thoughts about speciation. The cover image is a phyletic analysis of bacteria chemotaxis systems. [Image: Kristin Wuichet, BioEnergy Science Center and Computer Science and Mathematics Division, Oak Ridge National Laboratory, and Department of Microbiology, University of Tennessee, TN ]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882