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Editors' Choice

L. Bryan Ray
27 July 2010: ec225.
The estrogen receptor β functions with and without its estrogen ligand. Abstract »  
Nancy R. Gough
27 July 2010: ec226.
Through gradients of inhibitors, fly spermatids control caspase activation to promote differentiation without death. Abstract »  
Wei Wong
27 July 2010: ec227.
PPAR{gamma} ligand drugs exert their antidiabetic effect by blocking the phosphorylation of PPAR{gamma} by Cdk5. Abstract »  
Paula A. Kiberstis
27 July 2010: ec228.
Identification of the origin of muscle weakness that accompanies a form of neonatal diabetes may lead to safer therapies. Abstract »  
Paula A. Kiberstis
27 July 2010: ec229.
Fat cells secrete an anti-inflammatory factor that has beneficial effects on metabolic health. Abstract »  
John F. Foley
27 July 2010: ec230.
Inside-out activation of the β2 integrin subunit CD11b inhibits Toll-like receptor signaling in macrophages. Abstract »  
Annalisa M. VanHook
27 July 2010: ec231.
The TSC1-TSC2 complex represses differentiation of germline stem cells in Drosophila. Abstract »  
Pamela J. Hines
27 July 2010: ec232.
A bacterial ion pump rescues visual function in damaged cone-photoreceptor cells in mouse models of retinitis pigmentosa. Abstract »  
Stella M. Hurtley
27 July 2010: ec233.
Signaling proteins are retained in the cilium by a diffusion barrier created by a member of the septin family. Abstract »  
Helen Pickersgill
27 July 2010: ec234.
Network modeling reveals an RNA splicing network in the brain and uncovers complex mechanisms of regulation. Abstract »  
L. Bryan Ray
27 July 2010: ec235.
Low-density lipoprotein receptor–related protein-1 promotes endocytosis that influences non–cell autonomous Notch signaling. Abstract »  


Research Articles

Moritz Kronlage, Jian Song, Lydia Sorokin, Katrin Isfort, Tanja Schwerdtle, Jens Leipziger, Bernard Robaye, Pamela B. Conley, Hee-Cheol Kim, Sarah Sargin, Peter Schön, Albrecht Schwab, and Peter J. Hanley
27 July 2010: ra55.
Amplification of outside-in chemotactic signaling by inside-out purinergic signaling drives macrophage migration. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Kazuhiro A. Fujita, Yu Toyoshima, Shinsuke Uda, Yu-ichi Ozaki, Hiroyuki Kubota, and Shinya Kuroda
27 July 2010: ra56.
The Akt pathway can serve as a signal decoupler, converting a weak receptor signal into a strong effector signal. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Ming Liu, Tit Meng Lim, and Yu Cai
27 July 2010: ra57.
Drosophila ovarian stem cells communicate with somatic cells to define the size of the stem cell niche. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Kole T. Roybal and Christoph Wülfing
27 July 2010: pe24.
PKC-{theta} functions differently in regulatory T cells, which may be linked to its exclusion from immune synapses. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882