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Editors' Choice

Nancy R. Gough
10 August 2010: ec241.
Eating spicy chili peppers may lower blood pressure. Abstract »  
L. Bryan Ray
10 August 2010: ec242.
A lipid kinase coordinates cell migration by binding to a small GTPase. Abstract »  
John F. Foley
10 August 2010: ec243.
The mammalian target of rapamycin complex 1 (mTORC1) stimulates metabolic pathways that include glycolysis and lipid biosynthesis. Abstract »  
Wei Wong
10 August 2010: ec244.
Degradation of the scaffold protein Dishevelled by autophagy inhibits Wnt signaling. Abstract »  
Elizabeth M. Adler
10 August 2010: ec245.
Depletion of mature B cells is protective against atherosclerosis in mouse models. Abstract »  
Nancy R. Gough
10 August 2010: ec246.
A cleaved form of Myc acts in the cytoplasm to regulate microtubule dynamics and contributes to muscle cell differentiation. Abstract »  
Guy Riddihough
10 August 2010: ec247.
The nuclease FAN1 acts with Fanconi anemia proteins to help repair damaged DNA. Abstract »  


Research Articles

Faruk Ramadani, Daniel J. Bolland, Fabien Garcon, Juliet L. Emery, Bart Vanhaesebroeck, Anne E. Corcoran, and Klaus Okkenhaug
10 August 2010: ra60.
Different isoforms of phosphatidylinositol 3-kinase have distinct roles in B cell receptor signaling. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Jose J. Limon and David A. Fruman
10 August 2010: pe25.
The p110{alpha} isoform of class IA phosphatidylinositol 3-kinases has a selective function in tonic B cell receptor signaling. Abstract »   Full Text »   PDF »  
Christof Niehrs and Michael Boutros
10 August 2010: pe26.
Activation of Wnt and Notch pathways requires endocytosis of receptor complexes to an acidified vesicular compartment. Abstract »   Full Text »   PDF »  



10 August 2010: er8.
The authors acknowledge an additional source of funding. Full Text »   PDF »  
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