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Editors' Choice

Wei Wong
17 August 2010: ec248.
Endosomes containing NGF and its receptor TrkA are transported in a retrograde fashion to induce synapse formation. Abstract »  
Elizabeth M. Adler
17 August 2010: ec249.
Phosphatidylcholine biosynthesis promotes ERK signaling and neurite formation in neuroblastoma cells. Abstract »  
John F. Foley
17 August 2010: ec250.
Smad proteins regulate the generation of microRNAs by binding to precursor molecules and promoting their processing. Abstract »  
Kristen L. Mueller
17 August 2010: ec251.
Gut-specific signaling pathways regulate immune cell–mediated tolerance in the intestine. Abstract »  
Guy Riddihough
17 August 2010: ec252.
A metabolite-sensing riboswitch regulates the splicing of a "selfish" group I self-splicing ribozyme. Abstract »  
Stella M. Hurtley
17 August 2010: ec253.
Cells clear misfolded and damaged proteins from the cell surface, sometimes frustrating attempts to treat protein-folding diseases. Abstract »  
L. Bryan Ray
17 August 2010: ec254.
Immunoglobulin receptors and T cell receptors use similar components, but with critical differences in coupling to intracellular signaling. Abstract »  


Research Articles

Virginie Mieulet, Lijun Yan, Caroline Choisy, Katherine Sully, Julia Procter, Andreas Kouroumalis, Steve Krywawych, Mario Pende, Steven C. Ley, Christophe Moinard, and Richard F. Lamb
17 August 2010: ra61.
Arginine is an essential nutrient that enables mice to produce proinflammatory cytokines. Editor's Summary »   Abstract »   Full Text »   PDF »  
Joseph E. Qualls, Geoffrey Neale, Amber M. Smith, Mi-Sun Koo, Ashley A. DeFreitas, Huiyuan Zhang, Gilla Kaplan, Stephanie S. Watowich, and Peter J. Murray
17 August 2010: ra62.
Mycobacteria trigger the production of cytokines that suppress immune responses in infected and uninfected macrophages. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Sidney M. Morris, Jr.
17 August 2010: pe27.
In addition to acting as an enzyme substrate, arginine functions as a regulatory molecule in immune cells. Abstract »   Full Text »   PDF »  



Elisabeth Fayard, Gerald Moncayo, Brian A. Hemmings, and Georg A. Holländer
17 August 2010: re5.
PI3K signaling is important in the development of normal and malignant thymocytes. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882