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Editors' Choice

Elizabeth M. Adler
24 August 2010: ec255.
Antagonizing ActRIIB signaling may provide a therapeutic approach to treating cancer cachexia. Abstract »  
Annalisa M. VanHook
24 August 2010: ec256.
Strigolactones inhibit branching by modulating auxin transport in Arabidopsis. Abstract »  
Kristen L. Mueller
24 August 2010: ec257.
A fungal protein binds to a host cell wall component to allow the fungus to escape immune responses. Abstract »  
Stella M. Hurtley
24 August 2010: ec258.
An intracellular bacterial pathogen interferes with host cell membrane trafficking. Abstract »  
Peter R. Stern
24 August 2010: ec259.
Ketamine, an anesthetic and recreational drug, rapidly increases synaptic signaling and antidepressant behavioral responses. Abstract »  
Kristen L. Mueller
24 August 2010: ec260.
A factor that regulates chromatin accessibility and recombination during immunoglobulin rearrangements is identified. Abstract »  
Stella M. Hurtley
24 August 2010: ec261.
An actin-dependent mechanism is involved in moving nuclei so that they are properly positioned for cell migration. Abstract »  

 

Podcasts

Michael J. Comb and Annalisa M. VanHook
24 August 2010: pc17.
A phosphoproteomic approach identifies potential targets for developing combination therapies to treat cancer. Abstract »   Full Text »   Podcast »  

 

Research Articles

Andreu Casali
24 August 2010: ra63.
A self-regulating receptor allows cells to maintain the appropriate balance of ligand-bound and unbound receptors. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Albrecht Moritz, Yu Li, Ailan Guo, Judit Villén, Yi Wang, Joan MacNeill, Jon Kornhauser, Kam Sprott, Jing Zhou, Anthony Possemato, Jian Min Ren, Peter Hornbeck, Lewis C. Cantley, Steven P. Gygi, John Rush, and Michael J. Comb
24 August 2010: ra64.
A phosphoproteomic analysis of signaling pathways downstream of oncogenic receptor tyrosine kinases identified potential therapeutic targets. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Vladimir Purvanov, Alexey Koval, and Vladimir L. Katanaev
24 August 2010: ra65.
Regulation of a small GTPase by a heterotrimeric G protein determines the outcome of signaling from the receptor Frizzled. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Sabine M. Schmid and Michael Hollmann
24 August 2010: pe28.
Three proteins act as a transsynaptic bridge at a major type of cerebellar synapse. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882