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ONLINE COVER In this week's Editorial Guide, Chief Scientific Editor Michael Yaffe quotes the White Queen from Through the Looking-Glass regarding believing impossible things and makes predictions for three seemingly impossible things from the past that may emerge as exciting new areas of signaling research. The image is Alice and the White Queen by John Tenniel from Through the Looking-Glass by Charles Lutwidge Dodgson. [Image: John Tenniel]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882