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Editors' Choice

Nancy R. Gough
14 September 2010: ec277.
By limiting reactive oxygen species production, autophagy promotes cellular response to interferon {gamma}. Abstract »  
Elizabeth M. Adler
14 September 2010: ec278.
{omega}-3 fatty acids signal through GPR120 to reduce inflammation and promote insulin sensitivity. Abstract »  
Annalisa M. VanHook
14 September 2010: ec279.
A purine derivative promotes expansion of multipotent hematopoietic stem cells by suppressing differentiation. Abstract »  
L. Bryan Ray
14 September 2010: ec280.
Distinct signaling properties of the TrkB neurotrophin receptor explain differential control of developmental cell death in the central and peripheral nervous systems. Abstract »  
Elizabeth M. Adler
14 September 2010: ec281.
Antibodies that promote phagocytosis through distinct mechanisms have synergistic effects against non-Hodgkin lymphoma. Abstract »  
Stella M. Hurtley
14 September 2010: ec282.
A gene involved in morphogenesis and ciliogenesis is mutated in patients with Bardet-Biedl syndrome. Abstract »  
Pamela J. Hines
14 September 2010: ec283.
Oscillations in gene expression define the positions of periodic lateral roots in a plant model. Abstract »  
Guy Riddihough
14 September 2010: ec284.
A protein implicated in stress, aging, and genome stability is required for the accurate repair of broken DNA. Abstract »  
Caroline Ash
14 September 2010: ec285.
Early immune priming limits malaria parasite infection of mosquitoes. Abstract »  

 

Editorial Guides

Nancy R. Gough
14 September 2010: eg8.
Domains provide evolution with tools for the creation of new functions. Abstract »   Full Text »   PDF »   Evolution Series III »  

 

Research Articles

Shaochun Yuan, Huiling Liu, Ming Gu, Liqun Xu, Shengfeng Huang, Zhenhua Ren, and Anlong Xu
14 September 2010: ra66.
Death domain–dependent signaling in the basal chordate amphioxus suggests that extrinsic apoptotic signaling is not restricted to vertebrates. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Gordana Apic and Robert B. Russell
14 September 2010: pe30.
Firm evidence for domain shuffling as a means of evolving new functions might lead us to the creation of combinations of practical benefit. Abstract »   Full Text »   PDF »  
Erich Bornberg-Bauer
14 September 2010: pe31.
Binding domains in signaling proteins can tolerate sequence variation but still bind ligands and be structurally stable. Abstract »   Full Text »   PDF »  

 

Reviews

John Colicelli
14 September 2010: re6.
Insights from the regulation of ABL-family tyrosine kinases could facilitate development of therapies for malignancies driven by ABL fusion proteins. Gloss »   Abstract »   Full Text »   PDF »  
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