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Cover Figure

ONLINE COVER This week features the third issue in the series about the evolution of signaling molecules and networks. The Editorial Guide describes examples of how protein domains can serve as a medium for evolution. The image depicts how sequence variation enables a protein domain to acquire new ligands. [Image: Preston Huey, Science]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882