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Editors' Choice

Elizabeth M. Adler
21 September 2010: ec286.
Changes in membrane thickness enable the bacterial histidine kinase DesK to act as a temperature sensor. Abstract »  
Nancy R. Gough
21 September 2010: ec287.
Defective Wnt signaling may contribute to a severe premature aging disease. Abstract »  
Wei Wong
21 September 2010: ec288.
Increased neuronal activity promotes the uptake of IGF-1 by the brain from the circulation. Abstract »  
L. Bryan Ray
21 September 2010: ec289.
Characterization of cancer cell metabolism provides evidence for a previously uncharacterized metabolic pathway. Abstract »  
Stella M. Hurtley
21 September 2010: ec290.
The translational speed of proteins influences whether they are cotranslationally degraded after arginylation. Abstract »  
Nancy R. Gough
21 September 2010: ec291.
Compromised T cell response to the complement system may contribute to chronic inflammatory diseases, such as rheumatoid arthritis. Abstract »  
Kristen L. Mueller
21 September 2010: ec292.
Compartmentalization of signaling components allows induction of distinct pathways downstream of a pathogen receptor. Abstract »  
Pamela J. Hines
21 September 2010: ec293.
The uptake transporter for a key neurotransmitter is regulated by a microRNA, yielding new insight into how Prozac functions. Abstract »  

 

Research Articles

Igor Astsaturov, Vladimir Ratushny, Anna Sukhanova, Margret B. Einarson, Tetyana Bagnyukova, Yan Zhou, Karthik Devarajan, Joshua S. Silverman, Nadezhda Tikhmyanova, Natalya Skobeleva, Anna Pecherskaya, Rochelle E. Nasto, Catherine Sharma, Sandra A. Jablonski, Ilya G. Serebriiskii, Louis M. Weiner, and Erica A. Golemis
21 September 2010: ra67.
A targeted RNAi screen reveals potential targets for combination approaches to cancer treatment. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Anna Lorentzen, Ali Kinkhabwala, Oliver Rocks, Nachiket Vartak, and Philippe I. H. Bastiaens
21 September 2010: ra68.
Active Ras is relayed between subcellular compartments by the acylation cycle. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Wendy B. Macklin
21 September 2010: pe32.
The lipid phosphatase PTEN and the scaffold protein Dlg1 restrict myelination in the peripheral nervous system. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882