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Editors' Choice

Wei Wong
28 September 2010: ec294.
Two tetraspanins reduce β-catenin–dependent signaling by promoting the extracellular release of this signaling protein in exosomes. Abstract »  
Elizabeth M. Adler
28 September 2010: ec295.
Vitamin D acts through its nuclear receptor to regulate FoxO function. Abstract »  
Nancy R. Gough
28 September 2010: ec296.
Unliganded PPAR{gamma} is proinflammatory, whereas agonist-bound PPAR{gamma} is anti-inflammatory. Abstract »  
Annalisa M. VanHook
28 September 2010: ec297.
Pheromones regulate olfactory plasticity in nematodes. Abstract »  
L. Bryan Ray
28 September 2010: ec298.
Noise suppression in biochemical circuits comes at an extreme cost. Abstract »  
Nancy R. Gough
28 September 2010: ec299.
β-arrestin connects stimulation of a G protein–coupled receptor to down-regulation of an ion channel. Abstract »  
Stella M. Hurtley
28 September 2010: ec300.
Altering the homeostasis of membrane-bound signaling molecules allows a bacterial pathogen to corrupt cell function. Abstract »  
Annalisa M. VanHook
28 September 2010: ec301.
Neuronal input is required for maintenance of epithelial progenitor cells in the mouse salivary gland. Abstract »  
Peter R. Stern
28 September 2010: ec302.
Dendrites of neurons are sensitive to the sequence of synaptic activation and can implement cortical computation. Abstract »  
Stella M. Hurtley
28 September 2010: ec303.
A protein implicated in neurodegeneration promotes the assembly of membrane fusion complexes. Abstract »  

 

Research Articles

Ping Che, John D. Bussell, Wenxu Zhou, Gonzalo M. Estavillo, Barry J. Pogson, and Steven M. Smith
28 September 2010: ra69.
BR signaling may integrate stress responses and growth processes to optimize growth under challenging environmental conditions. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Matthew D. Fuller, Michelle A. Emrick, Martin Sadilek, Todd Scheuer, and William A. Catterall
28 September 2010: ra70.
Stimulation of cardiac Ca2+ channel activity by PKA in the fight-or-flight response requires an autoinhibitory complex with the distal C-terminal domain and a kinase anchoring protein. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Xuehua Xu, Tobias Meckel, Joseph A. Brzostowski, Jianshe Yan, Martin Meier-Schellersheim, and Tian Jin
28 September 2010: ra71.
Imaging analyses and computer simulations suggest that a GPCR and its G protein associate only in the presence of ligand. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Johannes W. Hell
28 September 2010: pe33.
Modulation of cardiac Ca2+ channels by protein kinase A in the fight-or-flight response involves their proteolytic processing and just the right amount of anchoring protein AKAP. Abstract »   Full Text »   PDF »  
Gennaro Napolitano and Michael Karin
28 September 2010: pe34.
Lipid second messengers are required for signaling through tumor necrosis factor and Toll-like receptors. Abstract »   Full Text »   PDF »  
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