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Editors' Choice

Wei Wong
5 October 2010: ec304.
A receptor family previously characterized as adhesion and costimulatory molecules also acts as sensors for gram-negative bacteria. Abstract »  
L. Bryan Ray
5 October 2010: ec305.
Activation of the B cell receptor appears to require release of the receptors from an autoinhibited, oligomeric state. Abstract »  
Nancy R. Gough
5 October 2010: ec306.
The type 1 transforming growth factor–β receptor phosphorylates elongation factor eEF1A1 to inhibit translation. Abstract »  
John F. Foley
5 October 2010: ec307.
More than 80% inhibition of ERK activity is required to induce regression of melanoma tumors. Abstract »  
L. Bryan Ray
5 October 2010: ec308.
The sensor protein that monitors depletion of intracellular calcium regulates two classes of calcium entry channels. Abstract »  
Kristen L. Mueller
5 October 2010: ec309.
Cigarette smoke promotes lung inflammation by hindering an enzyme that degrades an immune cell chemoattractant. Abstract »  
L. Bryan Ray
5 October 2010: ec310.
Cation channel genes encode for a transducer molecule that converts mechanical stimuli into cell signaling. Abstract »  
Caroline Ash
5 October 2010: ec311.
The genome of a third mosquito species reveals distinctions related to vector capacities and habitat preferences. Abstract »  



Dirk M. Hermann and Annalisa M. VanHook
5 October 2010: pc18.
Inhibition of apolipoprotein E signaling is a potential clinical strategy for enhancing the delivery of neuroprotective drugs to the brain after ischemic stroke. Abstract »   Full Text »   Podcast »  


Research Articles

Ayman ElAli and Dirk M. Hermann
5 October 2010: ra72.
Apolipoprotein E regulates ATP-binding cassette drug transporters in the ischemic brain, thereby controlling the brain-to-blood drug distribution. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
R. Douglas Fields and Yingchun Ni
5 October 2010: ra73.
Axonal swelling allows neurons to communicate with glia by ATP released from volume-activated anion channels. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Pablo E. Visconti and Harvey M. Florman
5 October 2010: pe35.
New evidence reveals a more complex scenario for early events in mammalian fertilization. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882