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Editors' Choice

Annalisa M. VanHook
26 October 2010: ec327.
Intrinsic differences in mTORC2-dependent Akt activation underlie the region-specific effects of neurofibromatosis-1 on glial progenitor cell development. Abstract »  
John F. Foley
26 October 2010: ec328.
Activation of Toll-like receptor 2 by the products of lipid oxidation promotes angiogenesis independently of vascular endothelial growth factor. Abstract »  
L. Bryan Ray
26 October 2010: ec329.
The protein kinase ATM is a sensor for reactive oxygen species. Abstract »  
Wei Wong
26 October 2010: ec330.
Bacterial chemoreceptors can be classified on the basis of whether ligands bind directly or indirectly. Abstract »  
Valda Vinson
26 October 2010: ec331.
A flurry of structural data provides sometimes conflicting insights into the M2 proton channel. Abstract »  
Kristen L. Mueller
26 October 2010: ec332.
A ligase regulates repression of the Foxp3 promoter to restrict differentiation of natural regulatory T cells. Abstract »  
Stella M. Hurtley
26 October 2010: ec333.
Membrane fusion proteins cooperate to promote rapid secretory vesicle exocytosis from neuroendocrine cells. Abstract »  



Sonja Vermeren and Annalisa M. VanHook
26 October 2010: pc19.
Disrupting activity of the guanosine triphosphatase-activating protein ARAP3 is a potential strategy for anti-angiogenic therapy. Abstract »   Full Text »   Podcast »  


Research Articles

Laure Gambardella, Myriam Hemberger, Bethany Hughes, Enrique Zudaire, Simon Andrews, and Sonja Vermeren
26 October 2010: ra76.
The guanosine triphosphatase–activating protein ARAP3 may be a target for antiangiogenic therapies. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Dequan Tian, Sarah M. P. Jacobo, David Billing, Anete Rozkalne, Steven D. Gage, Theodora Anagnostou, Hermann Pavenstädt, Hsiang-Hao Hsu, Johannes Schlondorff, Arnolt Ramos, and Anna Greka
26 October 2010: ra77.
Coupling TRPC5 and TRPC6 calcium channels to different Rho GTPases allows calcium to both promote and inhibit cell migration. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Thomas A. Masters, Véronique Calleja, Daven A. Armoogum, Richard J. Marsh, Christopher J. Applebee, Michel Laguerre, Angus J. Bain, and Banafshé Larijani
26 October 2010: ra78.
Spatial and temporal regulation of the homodimerization of PDK1 modulates its activity. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Jeffrey D. Axelrod
26 October 2010: pe38.
New ways to understand lateral inhibition in patterning sensory bristles in the fruit fly are proposed. Abstract »   Full Text »   PDF »  



Andreas Bergmann and Hermann Steller
26 October 2010: re8.
Cells undergoing stress- or injury-induced apoptosis can stimulate tissue regeneration by promoting stem or progenitor cell proliferation. Gloss »   Abstract »   Full Text »   PDF »  



26 October 2010: er10.
The authors correct an error in panel B of Figure S8 of the Supplementary Materials. Full Text »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882