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Editors' Choice

Wei Wong
2 November 2010: ec334.
The Solomon’s lily targets odorant receptors that enable drosophilids to detect odors from their food source. Abstract »  
Elizabeth M. Adler
2 November 2010: ec335.
Glial migration in the fly peripheral nervous system depends on an axonal gradient of Fasciclin2. Abstract »  
L. Bryan Ray
2 November 2010: ec336.
The early endosome, rather than the cell membrane, appears to be the critical location of signaling by the developmental morphogen receptor Toll in Drosophila. Abstract »  
Annalisa M. VanHook
2 November 2010: ec337.
A mutant screen identifies a third pathway through which CLAVATA3 regulates stem cell proliferation. Abstract »  
Valda Vinson
2 November 2010: ec338.
The structure of a chloride transporter and its regulatory domain provides insight into the ion-exchange mechanism. Abstract »  
Kristen L. Mueller
2 November 2010: ec339.
Immune cells develop to preempt intestinal colonization by microbial symbionts. Abstract »  


Editorial Guides

Wei Wong
2 November 2010: eg10.
Signaling pathways can regulate gene expression—and vice versa. Abstract »   Full Text »   PDF »  


Research Articles

Nitin Bhardwaj, Philip M. Kim, and Mark B. Gerstein
2 November 2010: ra79.
Transcriptional regulatory networks appear to have an organization similar to a corporation, with top-level managers having the most influence. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Zhanwen Du, Jing Song, Yong Wang, Yiqing Zhao, Kishore Guda, Shuming Yang, Hung-Ying Kao, Yan Xu, Joseph Willis, Sanford D. Markowitz, David Sedwick, Robert M. Ewing, and Zhenghe Wang
2 November 2010: ra80.
Degradation of a DNA methyltransferase implicated in cancer is determined by its acetylation status. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Lin He
2 November 2010: pe39.
The abundance of the tumor suppressor PTEN is modulated by microRNAs and pseudogenes. Abstract »   Full Text »   PDF »  
Michael A. Shi and Guo-Ping Shi
2 November 2010: pe40.
MicroRNAs can help maintain healthy cardiovascular systems or contribute to the pathogenesis of cardiovascular diseases. Abstract »   Full Text »   PDF »  



Hichem Miraoui and Pierre J. Marie
2 November 2010: re9.
Crosstalk of fibroblast growth factor signaling with other pathways may offer therapeutic strategies for skeletal dysplasias. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882