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Editors' Choice

John F. Foley
9 November 2010: ec340.
Agonists of bitter taste receptors in the airways induce bronchodilation in a mouse model of asthma. Abstract »  
Elizabeth M. Adler
9 November 2010: ec341.
Progestins act through RANKL to promote mammary tumor formation. Abstract »  
Annalisa M. VanHook
9 November 2010: ec342.
The Hippo signaling target Yap is dispensable for homeostasis of the intestinal epithelium but is required for regeneration. Abstract »  
L. Bryan Ray
9 November 2010: ec343.
Calmodulin appears to function in control of synaptic properties that vary in the front- and hindbrain. Abstract »  
Peter R. Stern
9 November 2010: ec344.
The neurotransmitter GABA is tonically released from cells through an anion channel with an unusually large pore. Abstract »  
Kristen L. Mueller
9 November 2010: ec345.
Tumor connective-tissue cells of mesenchymal origin suppress antitumor immune responses. Abstract »  


Editorial Guides

Elizabeth M. Adler
9 November 2010: eg11.
Complementing the 5 November Science Special Issue, this issue highlights glial cell function, development, and disease. Abstract »   Full Text »   PDF »  


Journal Club

Joseph Mathew Antony
9 November 2010: jc8.
Microglia modulate neurobehavior. Abstract »   Full Text »   PDF »  



R. Douglas Fields and Annalisa M. VanHook
9 November 2010: pc20.
A nonvesicular, nonsynaptic form of communication between axons and neighboring cells may play a role under normal conditions and in disease. Abstract »   Full Text »   Podcast »  


Research Articles

Qi-Wen Fan, Christine Cheng, Chris Hackett, Morri Feldman, Benjamin T. Houseman, Theodore Nicolaides, Daphne Haas-Kogan, C. David James, Scott A. Oakes, Jayanta Debnath, Kevan M. Shokat, and William A. Weiss
9 November 2010: ra81.
Combined inhibition of PI3K, mTOR, and autophagy promotes glioma cell death. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Klaus Ballanyi, Bogdan Panaitescu, and Araya Ruangkittisakul
9 November 2010: pe41.
Astrocytes sense the need to breathe. Abstract »   Full Text »   PDF »   Movies »  



9 November 2010: er11.
The authors note that the correct spelling of author Hermann Pavenstaedt is Hermann Pavenstädt. Full Text »   PDF »  



Li Li, B. Ian Hutchins, and Katherine Kalil
9 November 2010: pt2.
Chemorepulsion and growth stimulation may cooperate to guide cortical axons. Abstract »   Full Text »   PDF »   Slideshow »  


Teaching Resources

R. Douglas Fields
9 November 2010: tr5.
Astrocyte signaling is apparent in movies of rat brain astrocytes cultured with fluorescent calcium indicator dyes. Abstract »   Full Text »   PDF »   Movies »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882