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Editors' Choice

L. Bryan Ray
16 November 2010: ec346.
A "futile cycle" of transcription allows a pathogenic organism to rapidly respond to conditions favoring sexual reproduction. Abstract »  
Wei Wong
16 November 2010: ec347.
Fluid flow activates the LKB1-AMPK pathway in cilia to inhibit mTORC1-mediated increases in cell size. Abstract »  
Elizabeth M. Adler
16 November 2010: ec348.
Targeting tonic GABA-mediated inhibition in the appropriate time frame may provide a therapeutic strategy to enhance recovery from stroke. Abstract »  
John F. Foley
16 November 2010: ec349.
Interferon-{gamma} promotes the activation of macrophages by facilitating chromatin remodeling of proinflammatory genes. Abstract »  
Pamela J. Hines
16 November 2010: ec350.
In Arabidopsis, development and disease use the same pollen-tube or hyphal tip-growing strategies. Abstract »  
Pamela J. Hines
16 November 2010: ec351.
A factor is identified that determines the amount of vasculature in the brain and, in doing so, affects brain function. Abstract »  
Pamela J. Hines
16 November 2010: ec352.
Optogenetics is applied to study development of the zebrafish pacemaker. Abstract »  
Valda Vinson
16 November 2010: ec353.
A crystal structure shows how the two components of a central signaling complex regulate each other. Abstract »  

 

Research Articles

Marek K. Korzeniowski, Isabel Martín Manjarrés, Peter Varnai, and Tamas Balla
16 November 2010: ra82.
A cytoplasmic domain in STIM1 acts as a decoy to block the ability of STIM1 to bind to and activate Orai1. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Yohei Mukai, Teruya Nakamura, Mai Yoshikawa, Yasuo Yoshioka, Shin-ichi Tsunoda, Shinsaku Nakagawa, Yuriko Yamagata, and Yasuo Tsutsumi
16 November 2010: ra83.
Structural differences in the binding of tumor necrosis factor to its two receptors may aid in the development of receptor-specific therapeutics. Editor's Summary »   Abstract »   Full Text »   PDF »  

 

Perspectives

Youjun Wang, Xiaoxiang Deng, and Donald L. Gill
16 November 2010: pe42.
Intramolecular interactions within STIM1 control activation of Orai1 channels. Abstract »   Full Text »   PDF »  
David Strutt and Jean-Paul Vincent
16 November 2010: pe43.
Rab5, a key effector of endocytosis, binds to Frizzled proteins, modulating their trafficking and signaling. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882