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Editors' Choice

Elizabeth M. Adler
30 November 2010: ec362.
TLR7 may provide a target for antipruritic therapy. Abstract »  
Wei Wong
30 November 2010: ec363.
The tyrosine kinase Zap70 has kinase-independent functions during T cell activation. Abstract »  
L. Bryan Ray
30 November 2010: ec364.
Induction of apoptosis requires dephosphorylation of a regulatory protein in the mitochondrial outer membrane. Abstract »  
Pamela J. Hines
30 November 2010: ec365.
A gene identified in the mouse may show the way to improved treatments for amblyopia, a condition of indistinct vision. Abstract »  
L. Bryan Ray
30 November 2010: ec366.
The promyelocytic leukemia protein likely influences apoptosis by influencing a calcium channel in the endoplasmic reticulum. Abstract »  
L. Bryan Ray
30 November 2010: ec367.
Cells engineered to detect a cancer-associated marker produce a protein that sensitizes them to an anticancer drug. Abstract »  

 

Research Articles

Lirong Chen, Jesse Placone, Lawrence Novicky, and Kalina Hristova
30 November 2010: ra86.
The extracellular domain of a receptor tyrosine kinase has opposing effects on dimerization depending on whether ligand is present. Editor's Summary »   Abstract »   Full Text »   PDF »  

 

Perspectives

Alex Engel and Gregory M. Barton
30 November 2010: pe45.
The endosomal compartment in which TLR9 is activated determines which cytokines are produced. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882