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Editors' Choice

John F. Foley
7 December 2010: ec368.
The pro-inflammatory cytokine tumor necrosis factor triggers cognitive decline after surgery. Abstract »  
Annalisa M. VanHook
7 December 2010: ec369.
mTORC2-mediated phosphorylation of Akt occurs during translation. Abstract »  
Nancy R. Gough
7 December 2010: ec370.
Mice without Lkb1 cannot keep making blood cells. Abstract »  
Elizabeth M. Adler
7 December 2010: ec371.
ERK can promote cell proliferation through a mechanism independent of its catalytic activity. Abstract »  
Peter R. Stern
7 December 2010: ec372.
Nerve injury increases the activity of an enzyme in the brain and contributes to chronic pain–related cortical sensitization. Abstract »  
Nancy R. Gough
7 December 2010: ec373.
Alternative splice variants of the receptor tyrosine kinase ErbB4 trigger proliferation or death. Abstract »  
L. Bryan Ray
7 December 2010: ec374.
Proapoptotic proteins act directly on mitochondrial "gatekeeper" proteins to initiate apoptotic events during mouse development. Abstract »  
Pamela J. Hines
7 December 2010: ec375.
An ancient link between cell death control and innate immune receptor function has been discovered in plants. Abstract »  
Laura M. Zahn
7 December 2010: ec376.
A network comparison of genetic interactions mapped at two conditions reveals genetic responses to DNA damage in yeast. Abstract »  
Laura M. Zahn
7 December 2010: ec377.
A homolog of a flowering time gene has evolved a flowering repression function, affecting the seasonal cold response in beet. Abstract »  

 

Editorial Guides

Wei Wong
7 December 2010: eg12.
Complementing the Science Special Issue, this issue highlights signaling pathways with roles in metabolism. Abstract »   Full Text »   PDF »  

 

Podcasts

Lan Huang and Annalisa M. VanHook
7 December 2010: pc22.
Oxidative stress induces separation of the catalytic and regulatory portions of the yeast 26S proteasome, enabling the catalytic core to degrade toxic oxidized proteins. Abstract »   Full Text »   Podcast »  

 

Research Articles

Jeremie Boucher, Yazmin Macotela, Olivier Bezy, Marcelo A. Mori, Kristina Kriauciunas, and C. Ronald Kahn
7 December 2010: ra87.
Cells lacking both insulin and IGF-1 receptors are resistant to apoptosis. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Xiaorong Wang, James Yen, Peter Kaiser, and Lan Huang
7 December 2010: ra88.
Oxidative stress triggers release of the core catalytic subunit of the yeast 26S proteasome, enabling degradation of toxic oxidized proteins. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Nicholas T. Ktistakis
7 December 2010: pe46.
Phosphatidic acid links changes in pH triggered by glucose metabolism to phospholipid biogenesis in yeast. Abstract »   Full Text »   PDF »  
Patrick Mehlen
7 December 2010: pe47.
Some receptor tyrosine kinases can activate apoptotic pathways in the absence of ligand. Abstract »   Full Text »   PDF »  

 

Protocols

Michael Schieder, Katrin Rötzer, Andrea Brüggemann, Martin Biel, and Christian Wahl-Schott
7 December 2010: pl3.
Glass chips and gentle isolation are the keys to recording channels from intracellular organelles. Abstract »   Full Text »   PDF »  

 

Research Resources

Ariel Bensimon, Alexander Schmidt, Yael Ziv, Ran Elkon, Shih-Ya Wang, David J. Chen, Ruedi Aebersold, and Yosef Shiloh
7 December 2010: rs3.
Quantitative phosphoproteomics suggests that kinases other than ATM participate in the initial phase of the cellular response to DNA double-strand breaks. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882