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ONLINE COVER This week, Science Signaling publishes a Focus Issue that complements the Science Special Issue on Metabolism. Highlights include an unexpected role in triggering apoptosis for the insulin receptor and the related IGF-1 receptor (known for their roles in metabolism and growth), a role for lipids as cellular sensors of glucose metabolism, and a mechanism whereby cells can survive oxidative stress by shifting the activity of the cell's protein degradation complex. The image shows an artist's depiction of the two processes of metabolism: building (anabolic) and disassembling (catabolic). [Image: Chris Bickel, AAAS]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882