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Editors' Choice

Nancy R. Gough
14 December 2010: ec378.
Inositol trisphosphate receptors (IP3Rs) are central to the neuronal response to endoplasmic reticulum stress. Abstract »  
John F. Foley
14 December 2010: ec379.
Insulin signaling stimulates the generation of the inositol pyrophosphate IP7, which inhibits the activation of Akt, thus attenuating insulin signaling. Abstract »  
L. Bryan Ray
14 December 2010: ec380.
A signaling pathway often activated in cancer cells influences aerobic glycolysis and growth factor receptor expression. Abstract »  
Nancy R. Gough
14 December 2010: ec381.
Hypoxic conditions activate the kinase ATM to inhibit a complex central to metabolism, mTORC1. Abstract »  
Stella M. Hurtley
14 December 2010: ec382.
An alternative signaling mechanism for nucleating unbranched actin filaments is required for skeletal muscle maturation. Abstract »  
Kristen L. Mueller
14 December 2010: ec383.
MHC class I alleles are the major genetic determinants associated with people able to control HIV infection without therapy. Abstract »  

 

Research Articles

Mikiya Otsuji, Yuya Terashima, Shuji Ishihara, Shinya Kuroda, and Kouji Matsushima
14 December 2010: ra89.
Simulations and observations of migrating cells suggest a model for feedback loops that regulate chemotaxis. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Peter V. Bozhkov, Andrei P. Smertenko, and Boris Zhivotovsky
14 December 2010: pe48.
The substrates of the metacaspase type of proteases are beginning to be identified. Abstract »   Full Text »   PDF »  
Kambiz Mousavi and Vittorio Sartorelli
14 December 2010: pe49.
A cytoplasmic form of c-Myc promotes microtubule stability and cell differentiation. Abstract »   Full Text »   PDF »  

 

Reviews

John P. O’Bryan
14 December 2010: re10.
The intersectin family of scaffolding proteins link signaling and endocytic pathways. Gloss »   Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882