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Cover Figure

ONLINE COVER This week features a Research Article that describes a signaling pathway that transmits mechanical force into increased bone cell proliferation, which may lead to the development of drugs targeting this pathway that could mimic the bone-building effects of mechanical stimulation. The image shows an artist's representation of an elbow connected to a force meter and a mechanical damper. [Image Credit: Chris Bickel, AAAS, and Thinkstock]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882