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Editors' Choice

Nancy R. Gough
21 December 2010: ec384.
Fly larvae detect high-intensity light all over their bodies, not just with their primitive eyes. Abstract »  
Elizabeth M. Adler
21 December 2010: ec385.
Disruption of the dopamine D1-D2 receptor complex may provide a therapeutic strategy against depression. Abstract »  
Annalisa M. VanHook
21 December 2010: ec386.
A viral kinase mimics the activity of Akt despite their lack of sequence similarity. Abstract »  
John F. Foley
21 December 2010: ec387.
Cells lacking mTORC2 activity exhibit defects in polarization and chemotaxis. Abstract »  
L. Bryan Ray
21 December 2010: ec388.
The protein kinase Greatwall controls cell division by phosphorylating and activating inhibitors of protein phosphatase 2A. Abstract »  
Elizabeth M. Adler
21 December 2010: ec389.
Mesenchymal stem cells contribute to the ability of Mycobacterium tuberculosis to establish a persistent infection. Abstract »  
Paula A. Kiberstis
21 December 2010: ec390.
A drug inhibiting the activation of ghrelin, a peptide that promotes weight gain, has beneficial metabolic effects in mice. Abstract »  
Nancy R. Gough
21 December 2010: ec391.
Addition of N-acetylglucosamine to the medium can substitute for glucose in maintaining cell growth, but not proliferation. Abstract »  
Laura M. Zahn
21 December 2010: ec392.
The central nervous system and the hormone ecdysone govern wing-size scaling in the tobacco hornworm. Abstract »  



Bernd Bodenmiller, Ruedi Aebersold, and Annalisa M. VanHook
21 December 2010: pc23.
Targeted removal of individual enzymes elicits changes throughout the entire network of kinases and phosphatases in yeast. Abstract »   Full Text »   Podcast »  


Research Articles

Oliver E. Sturm, Richard Orton, Joan Grindlay, Marc Birtwistle, Vladislav Vyshemirsky, David Gilbert, Muffy Calder, Andrew Pitt, Boris Kholodenko, and Walter Kolch
21 December 2010: ra90.
Analysis of ERK pathway circuitry suggests appropriate targets for inhibition, providing a guide for drug development. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Hema Rangaswami, Raphaela Schwappacher, Nisha Marathe, Shunhui Zhuang, Darren E. Casteel, Bodo Haas, Yong Chen, Alexander Pfeifer, Hisashi Kato, Sanford Shattil, Gerry R. Boss, and Renate B. Pilz
21 December 2010: ra91.
Drugs that activate protein kinase G could mimic the bone-building effects of mechanical stimulation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Yuri Sykulev
21 December 2010: pe50.
The kinetics of TCR signaling influence the quality of the T cell response. Abstract »   Full Text »   PDF »   Animations »  
Joseph P. Bidwell and Fredrick M. Pavalko
21 December 2010: pe51.
Mechanical cues at the bone cell membrane can alter gene transcription through various signaling pathways. Abstract »   Full Text »   PDF »  


Research Resources

Bernd Bodenmiller, Stefanie Wanka, Claudine Kraft, Jörg Urban, David Campbell, Patrick G. Pedrioli, Bertran Gerrits, Paola Picotti, Henry Lam, Olga Vitek, Mi-Youn Brusniak, Bernd Roschitzki, Chao Zhang, Kevan M. Shokat, Ralph Schlapbach, Alejandro Colman-Lerner, Garry P. Nolan, Alexey I. Nesvizhskii, Matthias Peter, Robbie Loewith, Christian von Mering, and Ruedi Aebersold
21 December 2010: rs4.
A system-wide analysis of protein phosphorylation in yeast reveals robustness in the network of kinases and phosphatases. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882