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Editors' Choice

Elizabeth M. Adler
4 January 2011: ec1.
Canonical Wnt signaling involves sequestration of glycogen synthase kinase 3. Abstract »  
Wei Wong
4 January 2011: ec2.
Caspase-3 plays an apoptosis-independent role in the early pathogenesis of Alzheimer’s disease. Abstract »  
Nancy R. Gough
4 January 2011: ec3.
The scaffold and ubiquitin ligase TRAF6 plays a key role in muscle wasting. Abstract »  
Annalisa M. VanHook
4 January 2011: ec4.
A phosphatase normally associated with cell cycle control is required for ciliogenesis in zebrafish. Abstract »  
Pamela J. Hines
4 January 2011: ec5.
A ubiquitination cascade regulates formation of cell adhesions that immature neurons require in the developing mouse brain. Abstract »  
Nancy R. Gough
4 January 2011: ec6.
By recruiting active protein phosphatase 2A (PP2A) complexes or a PP2A inhibitor, the UNC5H2 dependence receptor triggers death or survival, respectively. Abstract »  
Valda Vinson
4 January 2011: ec7.
A double safety-catch mechanism controls amplification of the complement cascade during immune responses. Abstract »  
Nancy R. Gough
4 January 2011: ec8.
An immune profile that is biased toward the TH2 anti-inflammatory side regulates hepatic metabolism and limits adipose inflammation. Abstract »  
Guy Riddihough
4 January 2011: ec9.
A molecular chaperone both buffers and potentiates the adaptive nature of genetic variation in yeast. Abstract »  


Editorial Guides

Elizabeth M. Adler
4 January 2011: eg1.
The editors highlight the year's cell signaling breakthroughs. Abstract »   Full Text »   PDF »  


Journal Club

Kapuganti J. Gupta
4 January 2011: jc1.
S-nitrosylation of mitochondrial proteins induces cell death in the plant pathogen defense response. Abstract »   Full Text »   PDF »  



Michael B. Yaffe and Annalisa M. VanHook
4 January 2011: pc1.
Chief Scientific Editor Michael Yaffe reviews the past year in Science Signaling. Abstract »   Full Text »   Podcast »  


Research Resources

Shu Kondo and Norbert Perrimon
4 January 2011: rs1.
The DNA damage response in Drosophila requires the replication preinitiation complex and the MUS312 nuclease complex. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882