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Editors' Choice

Wei Wong
18 January 2011: ec15.
Reactive oxygen species generated by mitochondria can activate the NLRP3 inflammasome. Abstract »  
Nancy R. Gough
18 January 2011: ec16.
The adipocyte hormone adiponectin stimulates ceramidase activity of its receptors to promote its beneficial effects on cell survival and metabolism. Abstract »  
Elizabeth M. Adler
18 January 2011: ec17.
A photoactivated adenylyl cyclase from the bacterium Beggiatoa represents a promising tool for optogenetic manipulation of cAMP. Abstract »  
L. Bryan Ray
18 January 2011: ec18.
Cyanobacteral circadian clock components are directly coupled to the metabolic status of the cell through interactions with adenine nucleotides. Abstract »  
Peter R. Stern
18 January 2011: ec19.
Merely sniffing women's negative emotional tears reduces sexual arousal in men. Abstract »  
Nancy R. Gough
18 January 2011: ec20.
The muscarinic acetylcholine receptor exhibits voltage-dependent gating currents that may enhance neurotransmitter release at cholinergic synapses. Abstract »  
L. Bryan Ray
18 January 2011: ec21.
Modeling of development in the fruit fly yields an algorithm useful in designing wireless communication networks. Abstract »  
Valda Vinson
18 January 2011: ec22.
Substitution of a destabilizing sequence has allowed crystallization of a key enzyme of the inflammatory response. Abstract »  


Research Articles

Tatsuya Endo, Morioh Kusakabe, Kazunori Sunadome, Takuya Yamamoto, and Eisuke Nishida
18 January 2011: ra2.
The kinase SGK1 participates in an intertissue survival pathway during the early stages of development. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Kamyar Hadian and Daniel Krappmann
18 January 2011: pe2.
The kinase ATM has a cytosolic scaffolding function in the activation of NF-{kappa}B in response to DNA damage. Abstract »   Full Text »   PDF »  



18 January 2011: er1.
The phenotypes of the wild-type and knockout mice were mistakenly transposed. Full Text »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882