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Editors' Choice

Nancy R. Gough
25 January 2011: ec23.
By promoting Ras depalmitoylation, the prolyl isomerase FKBP12 regulates Ras trafficking and activity. Abstract »  
Elizabeth M. Adler
25 January 2011: ec24.
Cholesterol depletion enhances the proteolytic cleavage and release of the adhesion molecule CD44 and can inhibit glioma cell migration. Abstract »  
Wei Wong
25 January 2011: ec25.
Robo4 acts as an in trans ligand for UNC5B in vascular endothelium to restrict angiogenesis. Abstract »  
John F. Foley
25 January 2011: ec26.
A protein complex involved in the targeting of vesicles to the plasma membrane also acts as a platform for components of the autophagy machinery. Abstract »  
Kristen L. Mueller
25 January 2011: ec27.
A viral homolog of a host microbial sensor inhibits viral detection by the host and subsequent antiviral immunity. Abstract »  
Kristen L. Mueller
25 January 2011: ec28.
Bacteria of the genus Clostridium promote the induction of suppressor T cells in the colons of mice. Abstract »  


Journal Club

Richard Berry
25 January 2011: jc2.
The Src family kinase Lck is activated prior to T cell receptor engagement and poised for action upon antigen binding. Abstract »   Full Text »   PDF »  



Shu Wakino, Yasunobu Okada, and Annalisa M. VanHook
25 January 2011: pc2.
Researchers discuss recent findings on how mechanical stretch regulates signaling pathways in adipocytes and in hypothalamic neurons. Abstract »   Full Text »   Podcast »  


Research Articles

Yoshikazu Hara, Shu Wakino, Yoshiyuki Tanabe, Maki Saito, Hirobumi Tokuyama, Naoki Washida, Satoru Tatematsu, Kyoko Yoshioka, Koichiro Homma, Kazuhiro Hasegawa, Hitoshi Minakuchi, Keiko Fujimura, Koji Hosoya, Koichi Hayashi, Koichi Nakayama, and Hiroshi Itoh
25 January 2011: ra3.
Mechanical stretch activates Rho-kinase in adipocytes, promoting obesity and obesity-related complications. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Leni S. Jacob, Xiaofeng Wu, Michael E. Dodge, Chih-Wei Fan, Ozlem Kulak, Baozhi Chen, Wei Tang, Baolin Wang, James F. Amatruda, and Lawrence Lum
25 January 2011: ra4.
Loss of the kinase and tumor suppressor Stk11 (Lkb1) has opposite effects on Hh and Wnt signaling. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Kaori Sato, Tomohiro Numata, Takeshi Saito, Yoichi Ueta, and Yasunobu Okada
25 January 2011: ra5.
The antidiuretic hormone arginine vasopressin (AVP) is also an autocrine signal, allowing the hypothalamic neurons that produce it to maintain their volume during hypotonic stress. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Christian Bronner
25 January 2011: pe3.
The protein stability of a DNA methyltransferase is determined by acetylation and ubiquitylation. Abstract »   Full Text »   PDF »  


Meeting Reports

Patrick Mehlen and Dale E. Bredesen
25 January 2011: mr2.
Discussion at a meeting in France focused on new insights into the biology of dependence receptors. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882