08 February 2011
Vol 4, Issue 159

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article that presents the crystal structure of the Arabidopsis thaliana G protein α subunit, AtGPA1. The solution of this structure and molecular dynamics simulations identified differences between AtGPA1 and mammalian G protein α subunits that account for the ability of AtGPA1 to become activated in the absence of canonical G protein–coupled receptors. The image shows the crystal structure of AtGPA1 (blue) bound to GTP-γS (red) and is based on PDB structure 2XTZ. [Image: Chris Bickel, AAAS]