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Editors' Choice

Nancy R. Gough
8 February 2011: ec35.
By stimulating metabolic flux through the pentose phosphate pathway, ATM promotes the production of nucleotides for DNA repair and limits production of reactive oxygen species. Abstract »  
Elizabeth M. Adler
8 February 2011: ec36.
O-linked β-N-acetylglucosamine transferase cleaves HCF-1, as well as glycosylating it, in a process necessary for its functional activation. Abstract »  
John F. Foley
8 February 2011: ec37.
A gain-of-function mutation in MyD88 promotes survival of a B cell lymphoma through activation of NF-{kappa}B and JAK-STAT signaling pathways. Abstract »  
Nancy R. Gough
8 February 2011: ec38.
Erythropoietin inhibits NF-{kappa}B activation in macrophages and thus limits proinflammatory signaling. Abstract »  
Wei Wong
8 February 2011: ec39.
Stress-induced activation of p38 promotes more efficient processing of USE-containing mRNAs, including that encoding thrombin. Abstract »  
Nancy R. Gough
8 February 2011: ec40.
Some viruses evade detection by encoding enzymes that modify the structures of their coding RNAs to match those of their hosts. Abstract »  
Stella M. Hurtley
8 February 2011: ec41.
A peptide-mediated translational pause facilitates the unconventional splicing of a messenger RNA on the endoplasmic reticulum. Abstract »  
Annalisa M. VanHook
8 February 2011: ec42.
Dissociation of a plant receptor kinase inhibitor from its substrate is mediated by tyrosine phosphorylation. Abstract »  
Peter R. Stern
8 February 2011: ec43.
The waveform of an action potential can be physiologically modified while it travels along the axon. Abstract »  
Pamela J. Hines
8 February 2011: ec44.
The transition from passive to active metabolic control of stomata and plant water balance occurred about 360 million years ago. Abstract »  

 

Research Articles

Janice C. Jones, Jeffrey W. Duffy, Mischa Machius, Brenda R. S. Temple, Henrik G. Dohlman, and Alan M. Jones
8 February 2011: ra8.
The Arabidopsis G protein {alpha} subunit exhibits properties necessary and sufficient for receptor-independent activation. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Elliott M. Ross
8 February 2011: pe5.
A crystal structure illuminates reciprocal regulation between a G protein and its effector. Abstract »   Full Text »   PDF »  
Peter J. M. Van Haastert
8 February 2011: pe6.
A model of pseudopod formation, splitting, and persistence describes how cells migrate. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882