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Editors' Choice

Wei Wong
15 February 2011: ec45.
Notch signaling occurs in Drosophila olfactory receptor neurons and promotes synaptic plasticity in mouse hippocampal neurons. Abstract »  
Nancy R. Gough
15 February 2011: ec46.
Without an intact ER stress pathway, osteoblasts fail to properly differentiate, resulting in skeletal dysplasia. Abstract »  
Paula A. Kiberstis
15 February 2011: ec47.
Potassium channel mutations drive both cell growth and hormone production in an adrenal tumor that causes severe hypertension. Abstract »  
Stella M. Hurtley
15 February 2011: ec48.
In times of stress, long-lived proteins increase their durability. Abstract »  
Elizabeth M. Adler
15 February 2011: ec49.
Caveolae buffer variations in membrane tension during the response to acute mechanical stress. Abstract »  
Nancy R. Gough
15 February 2011: ec50.
Interactions at the cell surface between the endoplasmic or sarcoplasmic reticulum localized inositol trisphosphate receptor and the plasma membrane localized transient receptor potential 3 are mediated by caveolin-1. Abstract »  
Caroline Ash
15 February 2011: ec51.
An RNA virus of a parasite binds to human Toll-like receptor 3 and modulates host immune responses to the parasite. Abstract »  
Stella M. Hurtley
15 February 2011: ec52.
Regulated deaggregation allows meningitis-causing bacteria to propagate to new host cells and migrate across epithelia. Abstract »  


Editorial Guides

Nancy R. Gough and Michael B. Yaffe
15 February 2011: eg2.
Massive data sets create challenges for annotation, sharing, and presentation. Abstract »   Full Text »   PDF »  


Research Articles

Rehan Ahmad, Hasan Rajabi, Michio Kosugi, Maya Datt Joshi, Maroof Alam, Baldev Vasir, Takeshi Kawano, Surender Kharbanda, and Donald Kufe
15 February 2011: ra9.
An inflammatory response of epithelial cells may be co-opted to promote cancer cell survival. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Jesper V. Olsen and Matthias Mann
15 February 2011: pe7.
Proteomics data need a reliability tag to allow scientists to discriminate among data sets in public repositories. Abstract »   Full Text »   PDF »  
Forest M. White
15 February 2011: pe8.
The production of false leads by automated curation of high-throughput proteomic data sets exerts a toll on biological research and advancement. Abstract »   Full Text »   PDF »  
H. Steven Wiley
15 February 2011: pe9.
Easy integration of biological data has enormous potential to drive advances in biology and medicine. Abstract »   Full Text »   PDF »  
Julio Saez-Rodriguez, Leonidas G. Alexopoulos, and Gustavo Stolovitzky
15 February 2011: pe10.
Standardized methods to link large, complex data sets to models are needed. Abstract »   Full Text »   PDF »  



Bang Wong
15 February 2011: pt1.
Judicious choice of graphical representations can improve visual communication. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882