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Editors' Choice

Wei Wong
22 February 2011: ec53.
Inositol polyphosphate multikinase stabilizes the mTORC1 complex and enhances amino acid–induced signaling. Abstract »  
Nancy R. Gough
22 February 2011: ec54.
Bone morphogenetic proteins (BMPs) bind the receptor neogenin to trigger pathways that inhibit BMP signaling through the transcriptional regulators Smads. Abstract »  
Annalisa M. VanHook
22 February 2011: ec55.
Progesterone opposes estrogen-induced uterine epithelial proliferation through the transcription factor Hand2. Abstract »  
Elizabeth M. Adler
22 February 2011: ec56.
Heterogeneity in AKT activity in cell populations depends on differences in phosphoinositide 3-kinase abundance. Abstract »  
Pamela J. Hines
22 February 2011: ec57.
Parasponia uses a mycorrhizal signaling receptor essential for arbuscle formation to control rhizobium nodule symbiosis. Abstract »  
Peter R. Stern
22 February 2011: ec58.
Tagging of cortical networks at the time of encoding is crucial for long-lasting associative memories. Abstract »  



Alexander Hoffmann and Annalisa M. VanHook
22 February 2011: pc3.
A transcriptional repressor acts as a gatekeeper to restrict the innate immune response to specific stimuli. Abstract »   Full Text »   Podcast »  


Research Articles

Chien-Hung Chen, Tattym Shaikenov, Timothy R. Peterson, Rakhan Aimbetov, Amangeldy K. Bissenbaev, Szu-Wei Lee, Juan Wu, Hui-Kuan Lin, and Dos D. Sarbassov
22 February 2011: ra10.
Cellular stress attenuates growth factor signaling through a phosphorylation event that blocks substrate access to the kinase complex mTORC2. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Christine S. Cheng, Kristyn E. Feldman, James Lee, Shilpi Verma, De-Bin Huang, Kim Huynh, Mikyoung Chang, Julia V. Ponomarenko, Shao-Cong Sun, Chris A. Benedict, Gourisankar Ghosh, and Alexander Hoffmann
22 February 2011: ra11.
Binding of NF-{kappa}B p50 homodimers to an interferon response element restricts interferon signaling and antiviral responses to only the appropriate stimuli. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  


Meeting Reports

Natalia Cuesta, Noa B. Martín-Cófreces, Cristina Murga, and Hisse M. van Santen
22 February 2011: mr3.
This meeting in Madrid focused on signaling by immune cells and regulation of and signaling by G protein–coupled receptors. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882