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Cover Figure

ONLINE COVER This week's issue features a Research Article describing how adenosine triphosphate (ATP) signaling through purinergic receptors reduces the immunosuppressive effects of regulatory T cells (Tregs). In addition, ATP induced the conversion of Tregs to proinflammatory cells. The image shows a section of mouse colon that exhibits infiltrating inflammatory cells because some of the Tregs in the tissue have been rendered ineffective by ATP. [Image: Michele Proietti, Institute for Research in Biomedicine, Bellinzona, Switzerland]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882