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Editors' Choice

Nancy R. Gough
1 March 2011: ec59.
To prevent destruction of self, inhibitory receptors block clustering of activating receptors and cause natural killer cells to disengage. Abstract »  
John F. Foley
1 March 2011: ec60.
Receptor activator of nuclear factor {kappa}B ligand (RANKL) produced by regulatory T cells triggers the metastasis of breast cancer cells. Abstract »  
Annalisa M. VanHook
1 March 2011: ec61.
A contact pheromone produced by females induces aggression in male squid. Abstract »  
Nancy R. Gough
1 March 2011: ec62.
Too much dihydrosphingosine 1-phosphate enhances degradation of photoreceptor membrane proteins and leads to retinal degeneration in flies. Abstract »  
Annalisa M. VanHook
1 March 2011: ec63.
AphA and LuxR are opposing forces in the Vibrio quorum sensing pathway. Abstract »  


Research Articles

Ursula Schenk, Michela Frascoli, Michele Proietti, Robert Geffers, Elisabetta Traggiai, Jan Buer, Camillo Ricordi, Astrid M. Westendorf, and Fabio Grassi
1 March 2011: ra12.
Purinergic signaling during inflammation converts immunosuppressive CD4+ T cells into proinflammatory ones. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Dominique Debanne and Sylvain Rama
1 March 2011: pe11.
The action potential waveform can be altered by astrocyte-mediated activation of neuronal glutamate receptors. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882