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Editors' Choice

L. Bryan Ray
8 March 2011: ec64.
Osteocalcin, a peptide hormone produced in bone cells, controls production of the steroid hormone testosterone in the testes. Abstract »  
Nancy R. Gough
8 March 2011: ec65.
A Stat3-regulated pathway leads to lysosomal membrane permeabilization and reduced inhibition of cathepsin activity to promote mammary gland involution. Abstract »  
Elizabeth M. Adler
8 March 2011: ec66.
Acetylation coordinates the DNA double-strand break processing with autophagy. Abstract »  
Wei Wong
8 March 2011: ec67.
A neurodegenerative disorder could be caused by decreased signaling through the Hippo pathway. Abstract »  
Annalisa M. VanHook
8 March 2011: ec68.
Amino acids induce signaling through mTORC2. Abstract »  
Nancy R. Gough
8 March 2011: ec69.
Oncogenic Ras mutants stimulate the first kinase in the MAPK pathway (Raf) and prevent SUMOylation-mediated inhibition of the second kinase, MEK. Abstract »  
Stella M. Hurtley
8 March 2011: ec70.
Mitosis starts when morphogen signaling levels have increased by half since the beginning of the cell cycle. Abstract »  
Pamela J. Hines
8 March 2011: ec71.
Natural-product effectors of disease resistance in Arabidopsis reveal complementary disabling mechanisms in the pathogen. Abstract »  
Paula A. Kiberstis
8 March 2011: ec72.
A rare but deadly form of human pancreatic cancer harbors mutations in chromatin remodeling genes. Abstract »  
Peter R. Stern
8 March 2011: ec73.
In rats, overexpression of a persistently active protein kinase C isoform enhances memories long after they have been formed. Abstract »  



Marcos González-Gaitán, Frank Jülicher, and Annalisa M. VanHook
8 March 2011: pc4.
Mathematical analysis reveals how a graded signal can induce a homogeneous response across a field of cells. Abstract »   Full Text »   Podcast »  


Research Articles

Atsuo T. Sasaki, Arkaitz Carracedo, Jason W. Locasale, Dimitrios Anastasiou, Koh Takeuchi, Emily Rose Kahoud, Sasson Haviv, John M. Asara, Pier Paolo Pandolfi, and Lewis C. Cantley
8 March 2011: ra13.
Cancers in which K-Ras activation drives tumor growth could be targeted by treatments blocking K-Ras ubiquitination. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Nicholas R. Sylvain, Ken Nguyen, and Stephen C. Bunnell
8 March 2011: ra14.
Scaffolding functions of Vav1 contribute to SLP-76 clustering and signaling downstream of the T cell receptor. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Cathie M. Pfleger
8 March 2011: pe12.
Ubiquitination of different Ras isoforms has distinct effects on abundance, activity, and access to effectors. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882