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Editors' Choice

Nancy R. Gough
15 March 2011: ec74.
Recruitment of hair stem cells with activating mutations in the Hedgehog pathway to sites of skin injury leads to tumor formation. Abstract »  
Elizabeth M. Adler
15 March 2011: ec75.
In the presence of interleukin-15, retinoic acid appears to promote an intestinal inflammatory response. Abstract »  
L. Bryan Ray
15 March 2011: ec76.
The light sensor rhodopsin appears to function also in temperature sensation in the fruit fly. Abstract »  
John F. Foley
15 March 2011: ec77.
An additional point of contact with its regulatory subunit distinguishes p110β from other class IA PI3K isoforms. Abstract »  
Wei Wong
15 March 2011: ec78.
Activation of integrins on oligodendrocytes promotes translation of the mRNA encoding a myelin sheath component. Abstract »  
Stella M. Hurtley
15 March 2011: ec79.
A virulence factor secreted by Listeria monocytogenes induces expression of interferon-stimulated genes. Abstract »  
L. Bryan Ray
15 March 2011: ec80.
Circadian control of liver metabolism is mediated by cycles of recruitment of the histone deacetylase HDAC3. Abstract »  
Laura M. Zahn
15 March 2011: ec81.
An epithelium in Dictyostelium discoideum suggests convergence between multicellular animals and slime molds. Abstract »  

 

Podcasts

Craig Montell and Annalisa M. VanHook
15 March 2011: pc5.
A protein required for light sensation also plays a role in thermosensing in the fruit fly. Abstract »   Full Text »   Podcast »  

 

Research Articles

Mei Wan, Jun Li, Katie Herbst, Jin Zhang, Bing Yu, Xiangwei Wu, Tao Qiu, Weiqi Lei, Charlotta Lindvall, Bart O. Williams, Hairong Ma, Fengjie Zhang, and Xu Cao
15 March 2011: ra15.
The receptor LRP6 associates with Gαs to promote cAMP signaling by various GPCRs. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  

 

Perspectives

Sean R. Cutler
15 March 2011: pe13.
The plant abscisic acid signaling components can be leveraged to inducibly control protein interactions in mammals. Abstract »   Full Text »   PDF »  

 

Research Resources

Fu-Sen Liang, Wen Qi Ho, and Gerald R. Crabtree
15 March 2011: rs2.
An abscisic acid–induced proximity system can be used in combination with other such systems to simultaneously control multiple cellular processes. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Kristoffer T. G. Rigbolt, Tatyana A. Prokhorova, Vyacheslav Akimov, Jeanette Henningsen, Pia T. Johansen, Irina Kratchmarova, Moustapha Kassem, Matthias Mann, Jesper V. Olsen, and Blagoy Blagoev
15 March 2011: rs3.
Dynamic phosphorylation during stem cell differentiation may control recruitment of DNA methyltransferases to silence genes that maintain pluripotency. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882