Contents

22 March 2011
Vol 4, Issue 165

About The Cover

Cover image expansion

Online Cover This week's issue features a Research Article that provides a systems-level analysis of the differential responses of different regions of the mouse small intestine to systemic tumor necrosis factor–α (TNF-α). Computational modeling of the experimental data predicted that the effects of TNF-α were mediated by the mitogen-activated protein kinase kinase MEK—a prediction that was verified in vivo in experiments with the MEK inhibitor PD325901. The image shows the structure of the inhibitor and an artist's representation of the mouse gut with the colors indicating regional responses to TNF-α. [Image: Chris Bickel, AAAS]