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Editors' Choice

Wei Wong
29 March 2011: ec89.
A glycoprotein secreted by a parasitic nematode inhibits TLR4 signaling and could be used to treat sepsis. Abstract »  
John F. Foley
29 March 2011: ec90.
An avian Toll-like receptor is cleaved and activated by virulence-associated fungal and bacterial proteases. Abstract »  
Kristen L. Mueller
29 March 2011: ec91.
CD40 immunotherapy shows efficacy in treating pancreatic cancer in mice and humans by eliciting antitumor immunity. Abstract »  
Elizabeth M. Adler
29 March 2011: ec92.
A fat-body–derived signal to glia leads to their release of insulin-like peptides to stimulate neuroblast reactivation. Abstract »  
L. Bryan Ray
29 March 2011: ec93.
Fibroblast growth factor 19 regulates liver metabolism through a mechanism distinct from that of insulin. Abstract »  


Editorial Guides

Elizabeth M. Adler and Nancy R. Gough
29 March 2011: eg3.
Understanding the pathways that mediate drug resistance is key to developing new cancer therapies. Abstract »   Full Text »   PDF »  



Thomas G. Graeber and Annalisa M. VanHook
29 March 2011: pc6.
Negative feedback mechanisms fail to limit Src family kinase activity in leukemias driven by the oncoprotein Bcr-Abl. Abstract »   Full Text »   Podcast »  


Research Articles

Annette S. Little, Kathryn Balmanno, Matthew J. Sale, Scott Newman, Jonathan R. Dry, Mark Hampson, Paul A. W. Edwards, Paul D. Smith, and Simon J. Cook
29 March 2011: ra17.
Resistance to cancer therapeutics targeting the second kinase in a three-kinase cascade involves amplification of the upstream kinase, not the inhibited kinase. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Liudmilla Rubbi, Björn Titz, Lauren Brown, Erica Galvan, Evangelia Komisopoulou, Sharon S. Chen, Tracey Low, Martik Tahmasian, Brian Skaggs, Markus Müschen, Matteo Pellegrini, and Thomas G. Graeber
29 March 2011: ra18.
Negative feedback fails to limit Src family kinase activity in the presence of Bcr-Abl, an oncoprotein that drives leukemia. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Slovénie Pyndiah, Satoshi Tanida, Kazi M. Ahmed, Erica K. Cassimere, Chungyoul Choe, and Daitoku Sakamuro
29 March 2011: ra19.
c-MYC promotes cisplatin resistance by enabling the increased activity of a DNA repair enzyme. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Shridar Ganesan
29 March 2011: pe15.
Enhanced capacity for DNA repair may contribute to chemoresistance in cancers with dysregulated c-MYC. Abstract »   Full Text »   PDF »  
Poulikos I. Poulikakos and David B. Solit
29 March 2011: pe16.
Amplification of an upstream kinase in a three-kinase module confers resistance to cancer drugs that target a downstream kinase. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882