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ONLINE COVER This week's issue of Science Signaling complements the Science special issue on cancer and focuses on understanding how research into signaling pathways that affect cancer cell survival and adaptation to drug treatment may lead to therapeutic approaches that overcome or prevent drug resistance (see the Editorial Guide for an introduction to this Focus Issue). The image shows the regression of melanoma in patients treated with an inhibitor of the kinase B-Raf. Mutations that promote the activity of this kinase are associated with various forms of cancer. [Image: Image supplied by Gideon Bollag of Plexxikon; reprinted with permission from Nature 467, 596 (2010)]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882