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Cover Figure

ONLINE COVER This week's issue features a Research Article demonstrating that poly(ADP-ribose) (PAR) binds to apoptosis-inducing factor (AIF) to trigger its release from mitochondria and induce parthanatos, a form of cell death distinct from apoptosis or necrosis. The images show sections of mouse brains bearing either wild-type AIF (top) or a form that does not bind PAR (bottom), following striatal injection of NMDA. [Image: Yingfei Wang, Johns Hopkins University School of Medicine]

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882