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Editors' Choice

Elizabeth M. Adler
5 April 2011: ec94.
Some antibiotics dampen the immune response to respiratory infection with influenza virus. Abstract »  
Wei Wong
5 April 2011: ec95.
A group of rhomboid-like proteins lacking catalytic activity inhibit EGFR signaling by promoting degradation of EGF family ligands. Abstract »  
Kristen L. Mueller
5 April 2011: ec96.
Chronic yeast infections in the absence of other infections result from genetic deficiencies in proinflammatory host responses. Abstract »  
Pamela J. Hines
5 April 2011: ec97.
A plant ultraviolet-B photoreceptor uses a tryptophan-based chromophore. Abstract »  
Stella M. Hurtley
5 April 2011: ec98.
Guanabenz, a small-molecule inhibitor, protects cells from lethal accrual of misfolded proteins in the endoplasmic reticulum. Abstract »  



Sophie Ugolini, Eric Vivier, and Annalisa M. VanHook
5 April 2011: pc7.
The responsiveness of activating NK cell receptors is determined by the distribution of inhibitory receptors. Abstract »   Full Text »   Podcast »  


Research Articles

Yingfei Wang, No Soo Kim, Jean-Francois Haince, Ho Chul Kang, Karen K. David, Shaida A. Andrabi, Guy G. Poirier, Valina L. Dawson, and Ted M. Dawson
5 April 2011: ra20.
Poly(ADP-ribose) binds to apoptosis-inducing factor to trigger its release from mitochondria and induce cell death. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Sophie Guia, Baptiste N. Jaeger, Stefan Piatek, Sébastien Mailfert, Tomasz Trombik, Aurore Fenis, Nicolas Chevrier, Thierry Walzer, Yann M. Kerdiles, Didier Marguet, Eric Vivier, and Sophie Ugolini
5 April 2011: ra21.
Signaling through inhibitory NK cell receptors determines the distribution, and hence responsiveness, of activating receptors. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Antje Krüger and Markus Ralser
5 April 2011: pe17.
By linking genome stability, the cell cycle, and carbon catabolism, ATM emerges as a central regulator of cancer cell metabolism. Abstract »   Full Text »   PDF »  
J. Jefferson P. Perry and John A. Tainer
5 April 2011: pe18.
Oxidation activates ATM, allowing this kinase to mediate antioxidant responses. Abstract »   Full Text »   PDF »  



Adam Byron, Jonathan D. Humphries, Mark D. Bass, David Knight, and Martin J. Humphries
5 April 2011: pt2.
A workflow for the proteomic analysis of integrin-associated complexes reveals ligand-specific adhesion networks. Abstract »   Full Text »   PDF »   Slideshow »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882