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Editors' Choice

John F. Foley
12 April 2011: ec99.
Recruitment of mitochondria by a fission factor to immune synapses in T cells modulates T cell receptor signal strength. Abstract »  
Nancy R. Gough
12 April 2011: ec100.
Cortical neurons rely on atypical Rho proteins Rnd2 and Rnd3 to inhibit RhoA in different compartments to allow proper migration during embryonic development. Abstract »  
Kristen L. Mueller
12 April 2011: ec101.
Regulation of adipose tissue macrophages by eosinophils reveals an unexpected role for eosinophils in metabolic homeostasis. Abstract »  
Elizabeth M. Adler
12 April 2011: ec102.
Rac1 binds to mTOR, influencing the localization and activity of both mTORC1 and mTORC2. Abstract »  
Wei Wong
12 April 2011: ec103.
Light-dependent phosphorylation of the auxin efflux carrier PIN3 determines its trafficking pattern in the hypocotyl endodermis. Abstract »  
Nancy R. Gough
12 April 2011: ec104.
Hedgehog signaling activates Wnt signaling to promote regeneration of the bladder urothelium after chemical injury or injury due to infection. Abstract »  
Stella M. Hurtley
12 April 2011: ec105.
A bioenergy-sensing pathway determines axon initiation and growth in neurons. Abstract »  


Research Articles

Yuka Nakajima, Kensuke Akaogi, Takashi Suzuki, Asami Osakabe, Chie Yamaguchi, Nanae Sunahara, Junji Ishida, Koichiro Kako, Sonoko Ogawa, Tetsuya Fujimura, Yukio Homma, Akiyoshi Fukamizu, Akiko Murayama, Keiji Kimura, Satoshi Inoue, and Junn Yanagisawa
12 April 2011: ra22.
Estrogens and antiestrogens exert their opposing effects on prostate tumor growth through ERβ and KLF5, but through distinct mechanisms. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Suhasini Kulkarni, Cassian Sitaru, Zoltan Jakus, Karen E. Anderson, George Damoulakis, Keith Davidson, Misa Hirose, Jatinder Juss, David Oxley, Tamara A. M. Chessa, Faruk Ramadani, Herve Guillou, Anne Segonds-Pichon, Anja Fritsch, Gavin E. Jarvis, Klaus Okkenhaug, Ralf Ludwig, Detlef Zillikens, Attila Mocsai, Bart Vanhaesebroeck, Len R. Stephens, and Phillip T. Hawkins
12 April 2011: ra23.
The β isoform of phosphoinositide 3-kinase may be an effective therapeutic target in inflammatory diseases. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Yuet-Kin Leung and Shuk-Mei Ho
12 April 2011: pe19.
ERβ promotes apoptosis in prostate cancer cells through an estrogen-independent mechanism. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882