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Editors' Choice

Nancy R. Gough
19 April 2011: ec106.
Without a functional Nav1.7 sodium channel, not only is the sense of pain lost, but so is the sense of smell. Abstract »  
L. Bryan Ray
19 April 2011: ec107.
Signaling protein receptors are segregated into different cell protrusions in Drosophila cells. Abstract »  
Nancy R. Gough
19 April 2011: ec108.
New structures for the energy-sensing kinase AMPK suggest a potential mechanism for adjusting the amount of activation to suit the cell’s energy status. Abstract »  
Elizabeth M. Adler
19 April 2011: ec109.
Alum’s adjuvant action depends on signaling pathways initiated by its binding to dendritic cell membrane lipids. Abstract »  
Annalisa M. VanHook
19 April 2011: ec110.
A phosphatidylinositol 4-kinase is required for proper Merlin localization and Hippo signaling during fly oocyte polarization. Abstract »  
Wei Wong
19 April 2011: ec111.
A ubiquitin E3 ligase promotes degradation of the regulatory subunit of PKA and thus enhances PKA signaling. Abstract »  
Paula A. Kiberstis
19 April 2011: ec112.
Transforming growth factor–β promotes aortic aneurysm formation through activation of its "noncanonical" signaling pathway. Abstract »  
Valda Vinson
19 April 2011: ec113.
Changes associated with conformationally selective agonist binding shed light on G protein–coupled receptor activation. Abstract »  


Research Articles

Séverine Pfirsch-Maisonnas, Meryem Aloulou, Ting Xu, Julien Claver, Yutaka Kanamaru, Meetu Tiwari, Pierre Launay, Renato C. Monteiro, and Ulrich Blank
19 April 2011: ra24.
Receptors with activating motifs are captured in inhibitory intracellular compartments and thereby prevented from signaling. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  
Tomoharu Yasuda, Kohei Kometani, Noriko Takahashi, Yuuki Imai, Yuichi Aiba, and Tomohiro Kurosaki
19 April 2011: ra25.
The differentiation of B cells into antibody-producing plasma cells requires extracellular signal–regulated kinases. Editor's Summary »   Abstract »   Full Text »   PDF »   Supplementary Materials »  



Lionel B. Ivashkiv
19 April 2011: pe20.
ITAM-mediated inhibition recruits SHP-1 to membrane lipid rafts and diverts activated receptors to an inhibitory intracellular compartment. Abstract »   Full Text »   PDF »  
David M. Allman and Michael P. Cancro
19 April 2011: pe21.
Extracellular signal–regulated kinase is critical for the generation of plasma cells. Abstract »   Full Text »   PDF »  
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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882